Severe hepatic events, including fatalities, reported in pregnant women receiving chronic therapy as part of combination treatment of HIV 1 infection; regardless of pregnancy status, women with CD4 cell counts greater than 250 cells mm3 should not initiate therapy unless benefit outweighs risk; it is unclear if pregnancy augments risk observed in non pregnant women how long does lasix take to reduce edema IMpassion031 Mittendorf EA, Zhang H, Barrios CH, Saji S, Jung KH, Hegg R, Koehler A, Sohn J, Iwata H, Telli ML, Ferrario C, Punie K, Penault Llorca F, Patel S, Duc AN, Liste Hermoso M, Maiya V, Molinero L, Chui SY, Harbeck N